Metadefender for Chrome is a Chrome browser extension which can scan downloads for malware with 40+ commercial antivirus engines: Bitdefender, Kaspersky, F-Secure, Avira, ESET, AVG and more.
Downloads are scanned automatically by default, so just click a file link, it's uploaded to Metadefender (file size limit is 80MB, VirusTotal's is 64MB), and a detailed report tells you which of the antivirus engines - if any - detected it as a threat.
Chrome will also download the file to your system at the same time, so this isn't as intrusive as it sounds. You're free to scan or inspect the file with your own security software, even run it as usual, and just check Metadefender's verdict later.
Still, it's possible to turn off this automatic scanning by clicking the "M" icon next to the address bar and clearing the "Scan all downloads" box. You can then scan individual files as required by right-clicking a link and selecting "Scan file...".
Metadefender provides a simple, fast and effective way to check your downloads for malware.