Iperius Backup Free is an interesting and very configurable free backup tool.
The program offers a clean and simple interface. You don't have to explore a host of nested menus to figure out exactly what it can do: everything you need is accessible via few buttons.
There are still plenty of options, though. When creating a backup, for instance, you can include multiple source files and folders. A powerful scheduler allows you to run particular jobs on certain days of the week or month, at regular intervals (every 12 hours, say), and even tricky timescales like "the third Tuesday of the month". Iperius Backup Free can also send emails when the backup is complete to report what's happened, and you can have the program launch particular applications before and after your backup job runs.
This is the free version, of course, and so it has some restrictions. The most significant being that the program can't copy open or locked files, so if, say, you run a backup while Outlook is open, then your PST file (Outlook's main data store) won't be included. It also doesn't include a Disaster Recovery drive image, so can't be used to restore a system which won't boot any more. Check the Iperius comparison page for more.
If you just need a straightforward file backup tool, though, Iperius Backup Free could be sufficient: it's small, easy to use and very configurable.
Note that Iperius Backup is now compatible with Windows 8/8.1/10 only.
Version 5.8.1 improvements (full changelog) include:
Backup ESXi and Hyper-V: various improvements and optimizations
Hyper-V Backup: Now you can pause (put in saved state) and restart virtual machines even from the network
VMware ESXi Backup: fixed an error in the restore due to the new port parameter
Hyper-V Backup: Fixed an issue that prevented virtual machines from being paused (put in saved state)
Fixed a "program not responding" issue when copying large files and the status window was invisible.
Fixed a problem in restoring individual files from drive image in case of paths with accented letters or unicode characters.